Antibacterial activity test of acne cream bawang dayak (Eleutherine bulbosa(Mill.) Urb) against Staphylococcus aureus

Ardhany, Syahrida Dian and Pratiwi, Ayu Sahirani and Novaryatiin, Susi (2019) Antibacterial activity test of acne cream bawang dayak (Eleutherine bulbosa(Mill.) Urb) against Staphylococcus aureus. In: he 6th International Conference on Pharmacy and Advanced Pharmaceutical Sciences (ICPAPS 2019), 14 - 15 Agustus 2019, Faculty of Pharmacy Gadjah Mada University. (Unpublished)

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Abstract

Acne vulgaris is not dangerous disease but it can lead depression, acne is type of skin disease caused by bacteria. One of the causes of acne is Staphylococcus aureus. Based on research before, extract ethanol of bawang dayak from Central Kalimantan can inhibit S.aureus, so in this research ethanolic extract was made in cream formulation to improve the efficiency of using traditional medicine. The aims of this present study were to formulate anti acne cream consist ethanolic extract of bawang dayak and evalute antibacterial activity of cream on day-0 and day-7 to see stability activity and preparation. The Methods of this study are cream formula of Bawang Dayak divided into 4 formulas with different concentration of ethanolic extract bawang dayak then was evaluated organoleptic characteristics, homogenity, pH, adhesion test, dispersion test and in vitro antibacterial test against S.aureus with diffusion method. The results show the homogeneity of the cream shows F3 dan F4 separate and non homogen on day-7 but all formula pH suitable for topical application. Antibacterial activity of antiacne cream bawang dayak was indicated from zone of inhibition, on day0 F1 = 11.50 ± 0.14 mm (weak activity), F2= 17.20 ± 0.85 mm (moderate activity), F3= 16.90 ± 0.28 mm (moderate activity) and F4= 17.45 ± 2.90mm (moderate activity) while on day-7 respectively F1= 10.25 ± 0.21 mm (weak activity), F2= 11.40 ± 0.28 mm (weak activity), F3= 13.35 ± 0.35 mm (moderate activity) and F4= 15.75 ± 1.20 mm (moderate activity), on day-7 zone of inhibition of all cream formula decrease but still can inhibit. So it can ve concluded that all Cream Formula potential against S. aureus but this study must be improved both of preparation and stability activity.

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