Identification of Metabolite Compounds and Biological Activity of Diplazium esculentum

Zannah, Fathul and Amin, Mohamad and Suwono, Hadi and Lukiati, Betty (2022) Identification of Metabolite Compounds and Biological Activity of Diplazium esculentum. International Journal Bio Automation, 26 (2). pp. 131-140. ISSN 2355-3537

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Official URL: https://biomed.bas.bg/bioautomation/2022/vol_26.2/...

Abstract

Diplazium esculentum is one of the medicinal plants used by Dayak tribes in Central Kalimantan to cure acne. The potential of D. esculentum can be proved through information on the active compounds of the extract obtained in decoction and infusa methods. Thus, a liquid chromatography-mass spectrophotometry (LC-MS)-based method is developed to identify the active compounds of D. esculentum extract in either decoction method or infusa method. The chemical compound potential of D. esculentum extract was then analysed using bioinformatics approach based upon the database of PASS online server. Results showed that the D. esculentum extract contained 81 chemical compounds in decoction method and 68 compounds in infusa method, in which the dominant compound was flavonoid. Moreover, PASS online web server analysis found 7 flavonoid compound groups potential as anti-acne containing antisebor, AR expression inhibitor and CYP1A1 inhibitor. This information could be very useful for designing a clinical test on plant natural compound potential for traditional drug development.

Item Type: Article
Uncontrolled Keywords: Medicinal plant, Fern, Anti-acne, Decoction and Infusa methods
Subjects: 500 Natural Science and Mathematics > 540 - 549 Chemistry > 546 Inorganic Chemistry
500 Natural Science and Mathematics > 570 - 579 Biology > 570 Biology
500 Natural Science and Mathematics > 580 - 589 Plants > 582 Specific Vegetative Characteristics > 582.1 Woody Plants > 582.12 Herbaceous
Divisions: Perpustakaan > Journals
Depositing User: Publikasi Library UMPR
Date Deposited: 26 Jun 2023 01:30
Last Modified: 26 Jun 2023 01:30
URI: http://repository.umpr.ac.id/id/eprint/390

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