Identification of Metabolite Compounds and Biological Activity of Diplazium esculentum

Zannah, Fathul and Amin, Mohamad and Suwono, Hadi and Lukiati, Betty (2022) Identification of Metabolite Compounds and Biological Activity of Diplazium esculentum. International Journal Bio Automation, 26 (2). pp. 131-140. ISSN 2355-3537

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Abstract

Diplazium esculentum is one of the medicinal plants used by Dayak tribes in Central Kalimantan to cure acne. The potential of D. esculentum can be proved through information on the active compounds of the extract obtained in decoction and infusa methods. Thus, a liquid chromatography-mass spectrophotometry (LC-MS)-based method is developed to identify the active compounds of D. esculentum extract in either decoction method or infusa method. The chemical compound potential of D. esculentum extract was then analysed using bioinformatics approach based upon the database of PASS online server. Results showed that the D. esculentum extract contained 81 chemical compounds in decoction method and 68 compounds in infusa method, in which the dominant compound was flavonoid. Moreover, PASS online web server analysis found 7 flavonoid compound groups potential as anti-acne containing antisebor, AR expression inhibitor and CYP1A1 inhibitor. This information could be very useful for designing a clinical test on plant natural compound potential for traditional drug development.

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