Medicinal chemistry of oxazines as promising agents in drug discovery

Zinad, Dhafer S. and Mahal, Ahmed and Mohapatra, Ranjan K. and Sarangi, Ashish K. and Pratama, Mohammad Rizki Fadhil (2020) Medicinal chemistry of oxazines as promising agents in drug discovery. Chemical Biology and Drug Design, 95 (1). pp. 16-47.

Text 1. Dokumen CBDD v95s1 2019.pdf Download (2MB)

Abstract

Oxazines have brought much synthetic interest due to their extensive biological activities. These are the important category of heterocycles, which may be formally derived from benzene and its reduction products by convenient substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few decades, oxazine derivatives have documented as worthy synthetic intermediates and also blessed with notable sedative, analgesic, anticonvulsant, antipyretic, antimicrobial, antitubercular, antimalarial, antioxidant, and anticancer activities. Nowadays, it is important to develop new classes of compounds with more effective mechanisms due to drug resistance activity in which the ability of drug to effectively treat disease can be reduced. The aim of the article is to collect and make a more generalized review on the synthesis of oxazine derivatives and their pharmaceutical and biological activities. We hope this review will provide ample references for the researchers concerned with azines in generally and oxazines in particular.

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